Oral Intake of Inosine 5′-Monophosphate in Mice Promotes the Absorption of Exogenous Fatty Acids and Their Conversion into Triglycerides though Enhancing the Phosphorylation of Adenosine 5′-Monophosphate-Activated Protein Kinase in the Liver, Leading to Lipohyperplasia

Inosine 5′-monophoaphate (IMP) is a food additive that promotes serious lipohyperplasia in the liver of C57/KsJ-db/db (db/db) mice. Thus, IMP taken orally by healthy mice might also damage their health. To date, how affects health after being animals still unclear. Therefore, we investigated C57BL/6J affected intake. Our data revealed administered 255 μM daily via oral gavage for 4 months caused hyperlipidemia and an increase body fat rate. The expressions acetyl-CoA carboxylase 1 (ACC1) phosphorylated 2 (ACC2) hepatocytes increased though administration IMP, promoting phosphorylation adenosine 5′-monophosphate-activated protein kinase (AMPK). conversion into triglycerides (TGs) was promoted ACC1. These TGs were transported from to avoid development non-alcoholic fatty disease (NAFLD), causing deficiency liver, then, ACC2 cytoplasm acids entering mitochondria through acid β-oxidation pathway, acids. showed enhanced absorption exogenous acids, which converted TGs, lipohyperplasia. In conclusion, excessive intake metabolic dysfunction adipose tissue.